A Walnut-Enriched Diet Reduces the Growth of LNCaP Human Prostate Cancer Xenografts in Nude Mice

By , , , , , , ,

Background

*Preliminary animal research has been investigating the potential benefit walnuts may have on fighting a variety of cancers including breast, prostate, and colorectal. This study does not support a change in human behavior. Please note, that these animal studies are provided as background and used to formulate hypotheses for additional research needed to determine the effects on humans.

Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas , USA,.

It was investigated whether a standard mouse diet (AIN-76A) supplemented with walnuts reduced the establishment and growth of LNCaP human prostate cancer cells in nude (nu/nu) mice. The walnut-enriched diet reduced the number of tumors and the growth of the LNCaP xenografts; 3 of 16 (18.7%) of the walnut-fed mice developed tumors; conversely, 14 of 32 mice (44.0%) of the control diet-fed animals developed tumors. Similarly, the xenografts in the walnut-fed animals grew more slowly than those in the control diet mice. The final average tumor size in the walnut-diet animals was roughly one-fourth the average size of the prostate tumors in the mice that ate the control diet.